Hua Tuo (died 208) was a renowned physician during the Eastern Han Dynasty and Three Kingdoms era of China. He was described as looking like "an immortal who had passed the gates of this life" and "a man with the complexion of a youth and a snowy beard". The Book of Later Han records Hua Tuo as the first person in China to use anesthesia during surgery. He used a general anesthetic combining wine with a herbal concoction called mafeisan (麻沸散 lit. "cannabis boil powder").
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